Off The Record
Beloved Actress Christina Applegate Shares Painful Health Update That’s Leaving Fans Heartbroken
Living with multiple sclerosis is a challenging reality that Christina Applegate has talked about.
Multiple sclerosis, a chronic inflammatory disease that impairs communication between the brain and nerves throughout the body, was identified as the Dead to Me star’s condition in 2021.
Numerous incapacitating symptoms, including chronic numbness, eyesight problems, and in rare instances, paralysis, can result from the illness.
Applegate, who is currently 53, has disclosed that the illness now defines her day-to-day existence. She recently provided a candid and emotional health update on the Making Space podcast with Hoda Kotb, calling the situation a “nightmare.”

“I am defined by it right now,” she said. “I’m three and a half years in. I have days where I can’t even walk to the bathroom, so I am defined by it.”
The emotional toll of having the neurological ailment was openly discussed by the Emmy-winning actress.
“I’m angry at it still, and there’s a lot of us out there who are newly diagnosed that are not quite ready to accept this reality,” she said. “I keep thinking that I’m just going to wake up from this nightmare, and it’s just going to be over.”
She also confessed that she feels like her symptoms are progressing: “I want to do these things, and I can’t, and it feels like I’m getting worse. And that’s disheartening.”
Still, Applegate’s holding on to a sliver of hope. “But then there’s like this voice inside of me that is like, ‘You’ve got to believe in a miracle. You’ve got to believe in another side of this.'”
Jamie-Lynn Sigler, co-host of the MeSsy podcast and a Married… with Children veteran, who has lived with multiple sclerosis for more than two decades, joined her on the show.
Despite their shared experiences, Applegate admitted she doesn’t always feel like a source of strength. “I feel like I’m not very inspiring,” she said.
“If someone listening to me goes, ‘Oh my God, I feel that way, and I feel like I’m not doing it right.’ There is no doing MS right,” she explained, to which Sigler agreed with her instantly: “No, there’s not.”
She also discussed how routine chores have become physically taxing, using a recent unpleasant dental visit as an example.
“I went to go to the dentist yesterday, and it was a half-an-hour appointment, and it was like the most miserable hour and a half of my life,” Applegate stated. “Just getting down my stairs, getting into the car, getting into the parking lot, getting into the elevator, going into the office, like the whole thing was not even an hour and a half.”
“And by the time I got home, I was like, ‘I can’t move anymore.’ And that’s, that’s the stuff that makes me (say) that I can’t accept it yet because I’m mad still,” she added
When Sigler first received her MS diagnosis, she experienced similar unfiltered feelings to Applegate but was afraid to show them.
“They were feelings that I didn’t think – I wouldn’t allow myself to feel or didn’t think I deserve to feel for way too long,” she said. “So I think in the beginning of her journey with this, for her to be able to express herself like this, I admire.”
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